(1) Background.Snake venom phosphodiesterases (SVPDEs) are among the least studied venom enzymes.In envenomation, they display various pathological effects, including induction of hypotension, inhibition of platelet aggregation, edema, and paralysis.Until now, there have been no 3D structural studies of these enzymes, thereby preventing structure&#
Pseudomonas aeruginosa two-component system LadS/PA0034 regulates macrophage phagocytosis via fimbrial protein cupA1
ABSTRACT Pseudomonas aeruginosa is one of the most common nosocomial pathogens worldwide, known for its virulence, drug resistance, and elaborate sensor-response network.The primary challenge encountered by pathogens during the initial stages of infection is the immune clearance arising from the host.The resident macrophages of barrier organs serve
Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body
The main microtubule organizing centre in the unicellular model organisms Saccharomyces emtek 2113 cerevisiae and Schizosaccharomyces pompe is the spindle pole body (SPB).The SPB is a multilayer structure, which duplicates exactly once per cell cycle.Unlike higher eukaryotic cells, both yeast model organisms undergo mitosis without breakdown of the